Book chapter
AGEPC: A Potent Calcium-Dependent Chemical Mediator in the Liver
Cellular Ca2+ Regulation, pp.203-212
Advances in Experimental Medicine and Biology, Springer US
1988
DOI: 10.1007/978-1-4757-0007-7_22
Abstract
AGEPC (i.e. 1-0-alkyl-2-acetyl- sn -glycero-3-phosphocholine) or platelet activating factor is a unique phosphoglyceride first described as a fluid phase mediator of platelet aggregation during immunoglobulin E-induced anaphylaxis in the rabbit (1,2). AGEPC is produced in response to various stimuli in a variety of cells including neutrophils, basophils, monocytes and mast cells (3-7), and is among the most potent mediators formed and released by biological tissues. AGEPC induces aggregation and degranulation of platelets and neutrophils at subnanomolar concentrations (8,9) and is thought to act by interaction with specific receptors (10–13). In platelets, AGEPC-induced aggregation is associated with the turnover of inositol phospholipids, production of phosphatidic acid and protein phosphorylation (12–15). Additional studies have indicated that AGEPC possesses diverse biological actions including contraction of smooth muscles (16–18), negative inotropic cardiac effects (19,20), vasoconstriction (21,22), and exocrine gland stimulation (23). We have recently found that AGEPC possesses a powerful regulatory effect on hepatic metabolism which is the subject of this report.
Details
- Title: Subtitle
- AGEPC: A Potent Calcium-Dependent Chemical Mediator in the Liver
- Creators
- Rory A FisherDenis B BuxtonDavid S LapointeDonald J HanahanMerle S Olson
- Resource Type
- Book chapter
- Publication Details
- Cellular Ca2+ Regulation, pp.203-212
- Publisher
- Springer US; Boston, MA
- Series
- Advances in Experimental Medicine and Biology
- DOI
- 10.1007/978-1-4757-0007-7_22
- ISSN
- 0065-2598
- Language
- English
- Date published
- 1988
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984070308702771
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