Book chapter
Acid-Sensing Ion Channels (ASICs) and pH in Synapse Physiology
Structural And Functional Organization Of The Synapse, pp.661-681
Springer US
2008
DOI: 10.1007/978-0-387-77232-5_22
Abstract
Although brain pH is tightly controlled, it can be more dynamic than commonly appreciated. Physiological fluctuations in extracellular pH provide ample opportunity for protons to influence synaptic signaling. A number of synaptic proteins are modified by extracellular pH. Of these, the acid sensing ion channels (ASICs) are gated by extracellular protons and thus they may be particularly well suited to respond to synaptic pH. Here we review extracellular pH changes that accompany neural activity, the synaptic localization of ASICs, and their known effects on synapse function. Results from manipulating ASICs in mice suggest important roles for synaptic ASICs in behavior and neurological disease.
Details
- Title: Subtitle
- Acid-Sensing Ion Channels (ASICs) and pH in Synapse Physiology
- Creators
- John A Wemmie - Department of Psychiatry Neuroscience Program and Department of Veterans Affairs Medical Center, Iowa City, IAXiang-ming Zha - Department of Internal Medicine and Howard Hughes Medical Institute, Iowa City, USAMichael J Welsh - Departments of Internal Medicine and Molecular Physiology and Howard Hughes Medical Institute, Iowa City, USA
- Resource Type
- Book chapter
- Publication Details
- Structural And Functional Organization Of The Synapse, pp.661-681
- DOI
- 10.1007/978-0-387-77232-5_22
- Publisher
- Springer US; Boston, MA
- Language
- English
- Date published
- 2008
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Psychiatry; Iowa Neuroscience Institute; Neurosurgery; Internal Medicine
- Record Identifier
- 9984066388402771
Metrics
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