Book chapter
Aging and the Brain
The Wiley Handbook on the Aging Mind and Brain, pp.37-60
John Wiley & Sons, Ltd
04/18/2018
DOI: 10.1002/9781118772034.ch3
Abstract
This chapter explores brain aging in the larger context of organismal aging, and examines how similar mechanisms drive the trajectory of age‐related changes in the brain and body. It reviews some of the reasons for age‐dependent deterioration of the organism, beyond simple entropy. It also reviews five cellular changes that are, in many ways, a consequence of chronological time, and examines how interactions between cells can alter, reset or accelerate the effects of these time‐dependent changes. The chapter emphasizes the interactions between neurons and non‐neuronal cells, brain and body, to highlight our current understanding that aging as a genetically regulated consequence of how cells and animals respond to each other and their environment. Protein homeostasis appears to play a special role in the normal aging of neurons as well as in age‐related neurodegenerative diseases, both of which are associated with the accumulation of diverse species of misfolded proteins in neurons.
Details
- Title: Subtitle
- Aging and the Brain
- Creators
- Veena PrahladMadhusudana Rao Chikka
- Contributors
- Matthew Rizzo (Editor)Steven Anderson (Editor)Bernd Fritzsch (Editor)
- Resource Type
- Book chapter
- Publication Details
- The Wiley Handbook on the Aging Mind and Brain, pp.37-60
- DOI
- 10.1002/9781118772034.ch3
- Publisher
- John Wiley & Sons, Ltd; Chichester, UK
- Number of pages
- 24
- Language
- English
- Date published
- 04/18/2018
- Academic Unit
- Neurology; Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070810502771
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