Book chapter
Alternatives to the Streptozotocin-Diabetic Rodent
International Review of Neurobiology, pp.89-112
International Review of Neurobiology, Elsevier
01/01/2016
DOI: 10.1016/bs.irn.2016.03.002
PMCID: PMC5577923
PMID: 27133146
Abstract
The study of diabetic neuropathy has relied primarily on the use of streptozotocin-treated rat and mouse models of type 1 diabetes. This chapter will review the creation and use of other rodent models that have been developed in order to investigate the contribution of factors besides insulin deficiency to the development and progression of diabetic neuropathy as it occurs in obesity, type 1 or type 2 diabetes. Diabetic peripheral neuropathy is a complex disorder with multiple mechanisms contributing to its development and progression. Even though many animal models have been developed and investigated, no single model can mimic diabetic peripheral neuropathy as it occurs in humans. Nonetheless, animal models can play an important role in improving our understanding of the etiology of diabetic peripheral neuropathy and in performing preclinical screening of potential new treatments. To date treatments found to be effective for diabetic peripheral neuropathy in rodent models have failed in clinical trials. However, with the identification of new endpoints for the early detection of diabetic peripheral neuropathy and the understanding that a successful treatment may require a combination therapeutic approach there is hope that an effective treatment will be found.
Details
- Title: Subtitle
- Alternatives to the Streptozotocin-Diabetic Rodent
- Creators
- M. A. Yorek - Iowa City VA Health Care System
- Contributors
- N A Calcutt (Editor)P Fernyhough (Editor)
- Resource Type
- Book chapter
- Publication Details
- International Review of Neurobiology, pp.89-112
- Series
- International Review of Neurobiology
- DOI
- 10.1016/bs.irn.2016.03.002
- PMID
- 27133146
- PMCID
- PMC5577923
- NLM abbreviation
- Int Rev Neurobiol
- eISSN
- 2162-5514
- ISSN
- 0074-7742
- Publisher
- Elsevier; SAN DIEGO
- Number of pages
- 24
- Grant note
- R01DK107399 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01 DK107399 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) 1I01RX000889-01A1 / VA; US Department of Veterans Affairs I01 RX000889 / RRD VA I01RX000889 / Veterans Affairs; US Department of Veterans Affairs
- Language
- English
- Date published
- 01/01/2016
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984359842802771
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