Book chapter
Animal Models of Pathological Aging
The Wiley Handbook on the Aging Mind and Brain, pp.61-77
John Wiley & Sons, Ltd
04/18/2018
DOI: 10.1002/9781118772034.ch4
Abstract
This chapter provides a reference for researchers and students interested in animal models for the study of pathological aging. It reviews different models in four key systems—nematode worm, fruit fly, rodent, and primate. The chapter focuses on four broad theoretical constructs that have been derived from animal models of aging: single‐gene mutations, caloric intake, oxidative stress, and protein instability. It discusses the strengths and weaknesses of the four key systems in the context of human diseases of aging. Caenorhabditis elegans is an elegant model for cellular and elementary systems‐level analysis of how aging‐related processes influence the nervous system. Drosophila melanogaster, powerfully models the genetics of aging. Rodents are also well suited to model human age‐related hearing loss. Nonhuman primates are excellent proxies for humans as they possess similar brain structure and age‐related degradation of the dopaminergic system.
Details
- Title: Subtitle
- Animal Models of Pathological Aging
- Creators
- Eric B EmmonsYoungcho KimNandakumar S Narayanan
- Contributors
- Matthew Rizzo (Editor)Steven Anderson (Editor)Bernd Fritzsch (Editor)
- Resource Type
- Book chapter
- Publication Details
- The Wiley Handbook on the Aging Mind and Brain, pp.61-77
- DOI
- 10.1002/9781118772034.ch4
- Publisher
- John Wiley & Sons, Ltd; Chichester, UK
- Number of pages
- 17
- Language
- English
- Date published
- 04/18/2018
- Academic Unit
- Neurology; Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070810302771
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