Book chapter
Antigens and Antigen-Presenting Molecules for γδ T Cells
Function and Specificity of γ/δ T Cells, pp.229-234
Current topics in microbiology and immunology, 173, Springer Berlin
1991
DOI: 10.1007/978-3-642-76492-9_32
PMID: 1833148
Abstract
The T cell receptor (TCR) γδ is expressed on a distinct subset of T cells (Brenner et al., 1986). Unlike the TCR αβ, little is known about γδ T cell recognition. TCR α and ß and TCR γ and δ genes are assembled during development by recombination of distinct gene segments (V, D, J). While the germline gene segment repertoire for both TCR γ and δ chains is small compared to the TCR αß, extensive junctional diversity is observed particularly in the TCR δ chain (reviewed in Brenner et al. 1988). The diversity resides in a region presumed to form the CDR3 homolog of the immunoglobulin molecule considered important in antigen recognition (Davis and Bjorkman, 1988). These structural features of the γδ TCR suggest a role for T cells bearing this receptor in specific antigen recognition.
Details
- Title: Subtitle
- Antigens and Antigen-Presenting Molecules for γδ T Cells
- Creators
- H Band - Laboratory of Immunochemistry, Dana Farber Cancer Institute, Boston, MAS A PorcelliG PanchamoorthyJ McLeanC T MoritaS IshikawaR L ModlinM B Brenner
- Resource Type
- Book chapter
- Publication Details
- Function and Specificity of γ/δ T Cells, pp.229-234
- Publisher
- Springer Berlin
- Series
- Current topics in microbiology and immunology; 173
- DOI
- 10.1007/978-3-642-76492-9_32
- PMID
- 1833148
- ISSN
- 0070-217X
- eISSN
- 2196-9965
- Language
- English
- Date published
- 1991
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094609102771
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