Book chapter
Autoantibodies in Paraneoplastic Pemphigus
Autoantibodies, pp.759-761
Elsevier Science B.V
1996
DOI: 10.1016/B978-044482383-0/50116-3
Abstract
This chapter discusses the pathogenetic role, methods of detection, and clinical use of paraneoplastic pemphigus (PNP) autoantibodies. The pathogenicity of PNP autoantibodies was demonstrated by passive transfer in the mouse model originally developed for pemphigus vulgaris. PNP is an autoimmune blistering disease caused by circulating autoantibodies associated with different types of neoplasia. This disease is characterized by an indirect immunofluorescence staining pattern in which circulating antibodies label both the cell surface of keratinocytes and the basement membrane zone. The antibodies bind to the cell surface of stratified squamous and other types of epithelia, as well as nonepithelial tissues. These antibodies are pathogenic and immunoprecipitate an antigenic complex of 250, 230, 210, 190, and 170 kd.
Details
- Title: Subtitle
- Autoantibodies in Paraneoplastic Pemphigus
- Creators
- José M. MascaróJanet A. FairleyGeorge J. GiudiceLuis A. Diaz
- Resource Type
- Book chapter
- Publication Details
- Autoantibodies, pp.759-761
- DOI
- 10.1016/B978-044482383-0/50116-3
- Publisher
- Elsevier Science B.V
- Language
- English
- Date published
- 1996
- Academic Unit
- Dermatology
- Record Identifier
- 9984296197802771
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