Book chapter
Autophagy in the liver
Autophagy in Health and Disease, pp.161-179
Elsevier, Second edition
2022
DOI: 10.1016/b978-0-12-822003-0.00014-0
Abstract
Abstract The liver is the second-largest organ in the body and orchestrates key metabolic and immunological functions. Following the discovery of lysosomes in the rat liver, hepatic autophagy has been recognized as one of the critical cellular mechanisms in liver physiology. Dysregulation of autophagy has been implicated in the pathogenesis of many human pathologies, including liver diseases such as nonalcoholic fatty liver disease (NAFLD). In this chapter, we first describe the physiological role of autophagy in the hepatocyte, the major liver cell type, and then we outline contributions of deficient autophagy in other liver cell types in the context of NAFLD.
Details
- Title: Subtitle
- Autophagy in the liver
- Creators
- Mark Li - University of IowaLing Yang - University of Iowa
- Resource Type
- Book chapter
- Publication Details
- Autophagy in Health and Disease, pp.161-179
- Edition
- Second edition
- Publisher
- Elsevier
- DOI
- 10.1016/b978-0-12-822003-0.00014-0
- Language
- English
- Date published
- 2022
- Academic Unit
- Molecular Physiology and Biophysics; Fraternal Order of Eagles Diabetes Research Center; Anatomy and Cell Biology
- Record Identifier
- 9984528098102771
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