B Cell Tumors as Models of B Lymphocyte Differentiation

Larry W Arnold; Paula M Lutz; Christopher A Pennell; Gail A Bishop; Ronald B Corley; Geoffrey Haughton; Nicola J LoCascio

doi:10.1201/9781351070010-6

Book chapter

B Cell Tumors as Models of B Lymphocyte Differentiation

Larry W Arnold, Paula M Lutz, Christopher A Pennell, Gail A Bishop, Ronald B Corley, Geoffrey Haughton and Nicola J LoCascio

B-Lymphocyte Differentiation, pp.109-134

CRC Press, 1

1986

DOI: 10.1201/9781351070010-6

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Abstract

This chapter presents examples of how B cell tumors have been used to provide information about the various stages of the B cell differentiation pathway. It deals with studies of how these tumors may be used to investigate the regulatory mechanisms which trigger progression from one differentiation stage to another. The differentiation of cells within the B cell lineage along the pathway toward antibody secretion has a number of recognizable steps. These steps include both activation and differentiation events. The isolation of cells at any one of the distinct stages of B cell differentiation is difficult. One approach to the analysis of B lymphocyte ontogeny and differentiation is to use immortal, clonal cell lines including lymphomas and plasmacytomas. A particularly useful application of malignant B cells is the identification and characterization of cell membrane antigens associated with B cell development and the definition of cell subsets within the differentiation pathway.

Monoclonal Antibodies

Cell Differentiation

Induce DNA Synthesis

Cell Lymphomas

Surface Immunoglobulin

pre-B Cell

Light Chain Gene

PFC

Cell Ontogeny

Cell Development

Thy-1 Antigen

Abelson Murine Leukemia Virus

Immunoglobulin Molecules

CH12 Cells

Immunoglobulin Gene

Human CLL Cell

Malignant Cell Lines

Cell Factors

La Antigen

Polyclonal Activators

Gene Rearrangements

Details

Title: Subtitle: B Cell Tumors as Models of B Lymphocyte Differentiation
Creators: Larry W Arnold
Paula M Lutz
Christopher A Pennell
Gail A Bishop - University of Iowa, Microbiology and Immunology
Ronald B Corley
Geoffrey Haughton
Nicola J LoCascio
Resource Type: Book chapter
Publication Details: B-Lymphocyte Differentiation, pp.109-134
Edition: 1
Publisher: CRC Press
DOI: 10.1201/9781351070010-6
Language: English
Date published: 1986
Academic Unit: President; Microbiology and Immunology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984297328502771

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