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Blood-Optic Nerve Barrier
Book chapter

Blood-Optic Nerve Barrier

Sohan Hayreh
Ischemic Optic Neuropathies, pp.79-84
Springer Berlin Heidelberg
2011
DOI: 10.1007/978-3-642-11852-4_4

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Abstract

The blood-optic nerve barrier is an important subject in any consideration of optic nerve and optic nerve head (ONH) vascular disorders. The capillaries in the ONH and the rest of the optic nerve, as in the retina [1–5] and in the central nervous system [6–10] have tight cell junctions between adjacent endothelial cells, without fenestration [11–13]. These tight junctions are responsible for the blood-optic nerve barrier, which has been shown by intravenous injection of tracer substances, such as horseradish peroxidase [14–16] and diaminoacridines [17].
Neurology Medicine & Public Health Rheumatology Ophthalmology

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