Book chapter
Cancer Genetics
Clinical Ophthalmic Oncology, pp.79-86
Springer International Publishing
03/13/2019
DOI: 10.1007/978-3-030-04489-3_7
Abstract
A fundamental characteristic of cancer cells is their ability to proliferate and survive outside of their normal physiologic context. This ability is acquired through genetic and epigenetic alterations that modify the cell’s interaction with its environment. As such, some of the most common cancer-related genes are involved in the cell cycle, cellular differentiation, apoptosis, and angiogenesis. These genes are often referred to as oncogenes or tumor suppressor genes, depending on whether cancer-causing mutations result in gain- or loss-of-function, respectively. Here we will review some of the genes and pathways that are deregulated in cancer.
Details
- Title: Subtitle
- Cancer Genetics
- Creators
- Elaine M Binkley - Department of Ophthalmology & Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, USALuke A Wiley - Department of Ophthalmology & Visual Sciences, Institute for Vision Research, University of Iowa, Iowa City, USA
- Resource Type
- Book chapter
- Publication Details
- Clinical Ophthalmic Oncology, pp.79-86
- DOI
- 10.1007/978-3-030-04489-3_7
- Publisher
- Springer International Publishing; Cham
- Language
- English
- Date published
- 03/13/2019
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984172264502771
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