Book chapter
Cardiac Metabolic Protection for the Newborn Heart
Cardiac Energy Metabolism in Health and Disease, pp.265-276
Advances in Biochemistry in Health and Disease, Springer New York
07/19/2014
DOI: 10.1007/978-1-4939-1227-8_17
Abstract
As the newborn heart transitions into the extrauterine environment, it emerges from a relatively hypoxic state, restricted predominately to glucose for energy, into an oxygen abundant environment in which a wider selection of substrates is available. Exposed to the unique milieu in utero, the fetal cardiac myocyte developed metabolic pathways that will subsequently adapt to postnatal life. Prior to the transition to a more adult-like metabolism, the newborn heart can take advantage of the metabolic profile developed in utero to protect itself during times of stress such as global ischemia and abrupt hypoxia. This relative tolerance to low oxygen levels and robust coronary perfusion of the neonatal heart have been exploited by surgeons to allow prolonged periods of bypass or cardiac arrest, facilitating repair of complex congenital heart defects. The ability of the newborn heart to utilize a variety of energy substrates has generated great interest in defining the optimal composition of cardioplegia solutions to enhance the ability of newborn myocardium to tolerate open heart surgery.
Details
- Title: Subtitle
- Cardiac Metabolic Protection for the Newborn Heart
- Creators
- J. Carter Ralphe - University of Wisconsin–MadisonThomas D. Scholz - University of Iowa
- Resource Type
- Book chapter
- Publication Details
- Cardiac Energy Metabolism in Health and Disease, pp.265-276
- Publisher
- Springer New York; New York, NY
- Series
- Advances in Biochemistry in Health and Disease
- DOI
- 10.1007/978-1-4939-1227-8_17
- Language
- English
- Date published
- 07/19/2014
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center; Child and Community Health; Cardiology
- Record Identifier
- 9984354052502771
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