Cardiovascular Disease and Aging

Ying Ann Chiao; Edward Lakatta; Zoltan Ungvari; Dao-Fu Dai; Peter Rabinovitch

doi:10.1007/978-3-319-23246-1_5

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Book chapter

Cardiovascular Disease and Aging

Ying Ann Chiao, Edward Lakatta, Zoltan Ungvari, Dao-Fu Dai and Peter Rabinovitch

Advances in Geroscience, pp.121-160

Springer International Publishing

01/01/2015

DOI: 10.1007/978-3-319-23246-1_5

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Abstract

Cardiovascular diseases are the leading cause of death for population over 65 years of age. With the progressive increase of population in this age group, it is crucial to understand the interaction between aging and cardiovascular diseases. Aging results in structural changes and functional decline of the cardiovascular system and is a major risk factor for cardiovascular diseases. Aging not only increases the prevalence of cardiovascular diseases but is also associated with impaired responses to cardiovascular diseases. This supports the notion that age-related changes in the cardiovascular system superimpose and interact with the pathophysiological mechanisms that lead to cardiovascular disease. This chapter will provide an overview of cardiovascular aging in humans and mammalian models, and discuss the recent advances in understanding how different hallmarks of aging play their roles in the pathogenesis of cardiovascular aging.

Vascular aging

Angiogenesis

Cardiovascular reserve

Arterial aging

Heart aging

Geroscience

Details

Title: Subtitle: Cardiovascular Disease and Aging
Creators: Ying Ann Chiao - Department of Pathology, University of Washington, Seattle, USA
Edward Lakatta - Laboratory of Cardiovascular Science, Biomedical Research Center, National Institute of Aging, Baltimore, USA
Zoltan Ungvari - Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Science Center, Oklahoma City, USA
Dao-Fu Dai - Department of Pathology, University of Washington, Seattle, USA
Peter Rabinovitch - Department of Pathology, University of Washington, Seattle, USA
Resource Type: Book chapter
Publication Details: Advances in Geroscience, pp.121-160
DOI: 10.1007/978-3-319-23246-1_5
Publisher: Springer International Publishing; Cham
Language: English
Date published: 01/01/2015
Academic Unit: Pathology; Iowa Neuroscience Institute; Radiation Oncology
Record Identifier: 9984070364002771

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