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Catastrophic Epilepsy and Hemispherotomy
Book chapter

Catastrophic Epilepsy and Hemispherotomy

Brian J Dlouhy and Matthew D Smyth
Textbook of Pediatric Neurosurgery, pp.2155-2167
Springer International Publishing
06/24/2020
DOI: 10.1007/978-3-319-72168-2_98

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Abstract

Many epilepsies that occur in early childhood are severe, intractable, result in intellectual and behavioral disability, and have the highest incidence of sudden unexpected death in epilepsy (SUDEP) (Sillanpaa and Shinnar 2010). Although the term “catastrophic epilepsies” is no longer the appropriate clinical classification for these epilepsies, it is an appropriate description. These epilepsies include Dravet syndrome, Ohtahara syndrome, West syndrome, migrating focal seizures Seizures of infancy, Lennox-Gastaut syndrome, Angelman syndrome, and Landau-Kleffner syndrome (Howard and Baraban 2017). These epilepsies can be challenging to treat and lack many surgical options outside of vagus nerve stimulation (VNS) or corpus callosotomy (Dlouhy et al. 2016).

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