Book chapter
Cells of respiratory epithelium
Lentivirus Gene Engineering Protocols, Vol.229, pp.287-298
Methods in molecular biology (Clifton, N.J.), 229, Humana Press
2003
DOI: 10.1385/1-59259-393-3:287
PMID: 12824638
Abstract
The goal of correcting such genetic lung diseases as cystic fibrosis could be achieved by vector-mediated gene transfer to airway epithelia. The principle of using viral vectors to complement genetic defects is well documented in cell culture and in animal models. Moreover, strategies for the successful implementation of gene transfer-based therapies for patients are beginning to emerge (1). However, the airway epithelium has evolved many defensive barriers against microbial invasion (2,3). Indeed, these same barriers likely impede gene transfer efficiency with viral and nonviral vectors (3).
Details
- Title: Subtitle
- Cells of respiratory epithelium
- Creators
- Patrick L Sinn - Department of Pediatrics, University of Iowa, College of Medicine, Iowa City, USAPaul B McCray Jr
- Resource Type
- Book chapter
- Publication Details
- Lentivirus Gene Engineering Protocols, Vol.229, pp.287-298
- Publisher
- Humana Press
- Series
- Methods in molecular biology (Clifton, N.J.); 229
- DOI
- 10.1385/1-59259-393-3:287
- PMID
- 12824638
- ISSN
- 1064-3745
- eISSN
- 1940-6029
- Language
- English
- Date published
- 2003
- Academic Unit
- Microbiology and Immunology; Pulmonary Medicine; Stead Family Department of Pediatrics; Internal Medicine
- Record Identifier
- 9984093598702771
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