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Cellular Glutathione Status Modulates PCB-Induced Stress Response and Apoptosis in Vascular Endothelial Cells
Book chapter

Cellular Glutathione Status Modulates PCB-Induced Stress Response and Apoptosis in Vascular Endothelial Cells

Rabih Slim, Michal Toborek, Larry W. Robertson, Hans-Joachim Lehmler and Bernhard Hennig
PCBs, p.313
The University Press of Kentucky
02/05/2015

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Abstract

There is evidence that certain environmental contaminants, such as coplanar polychlorinated biphenyl (PCB) congeners and related compounds, e.g., 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), are associated with vascular endothelial cell dysfunction (Stegeman et al., 1995; Toborek et al., 1995; Hennig et al.,1999). PCBs and their metabolites may remain in the blood circulation for extended time periods. Endothelial cells are in direct contact with plasma components and other circulating substances and are thus vulnerable to PCB insult, that can lead to severe endothelial cell dysfunction. Apoptotic endothelial cell death and other types of endothelial dysfunction may be critical events in vascular diseases such as atherosclerosis
 Oxidative Stress Cytology Cell Biology Materials Science Cell Physiology Genetics Physiology Stress Response Arteriosclerosis Physical Sciences Applied Sciences Biological Sciences Apoptosis Health sciences Epithelial cells Genetic variation DNA damage Materials Homeostasis Cultured cells Biology Physiological responses Biopolymers Population genetics Calcium binding proteins Proteins Medical conditions Vascular diseases Carrier proteins DNA fragmentation Atherosclerosis Polymers Annexins Chemical compounds Genetic mutation Cells Endothelial cells Chemicals Diseases Chemistry Arterial occlusive diseases Cell death Contaminants Physiological regulation Cardiovascular diseases Metabolic stress

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