Cellular Mechanisms of Calcium Elevation Involved in Long Term Memory

K. T. Blackwell; T. P. Vogl; D. L. Alkon

doi:10.1007/978-1-4615-4831-7_23

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Book chapter

Cellular Mechanisms of Calcium Elevation Involved in Long Term Memory

K. T. Blackwell, T. P. Vogl and D. L. Alkon

Computational Neuroscience, pp.137-142

Springer US

01/01/1998

DOI: 10.1007/978-1-4615-4831-7_23

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Abstract

Hermissenda crassicornis is a shell-less marine snail that can be classically conditioned to associate light (the conditioned stimulus) with turbulence (the unconditioned stimulus). Acquisition of the association is critically dependent on elevation of intracellular calcium in the B cell soma, the location of memory storage. The source of calcium elevation has implications for cellular mechanisms underlying memory storage. To investigate sources of calcium elevation, a model of calcium dynamics in the photoreceptor was developed. Mechanisms of calcium diffusion, buffering and light activated release from intracellular stores were included in the model. Simulations show that release of calcium from intracellular stores is a significant source of calcium in the soma and may be the activating signal for the light-induced potassium current.

Calcium Concentration

Calcium Release

Conditioned Stimulus

Potassium Current

Unconditioned Stimulus

Details

Title: Subtitle: Cellular Mechanisms of Calcium Elevation Involved in Long Term Memory
Creators: K. T. Blackwell - George Mason University
T. P. Vogl - George Mason University
D. L. Alkon - National Institute of Neurological Disorders and Stroke
Resource Type: Book chapter
Publication Details: Computational Neuroscience, pp.137-142
DOI: 10.1007/978-1-4615-4831-7_23
Publisher: Springer US; Boston, MA
Language: English
Date published: 01/01/1998
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
Record Identifier: 9984573939102771

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