Book chapter
Cellular and Molecular Biology of Cancer Cell Extravasation
Signaling Pathways and Molecular Mediators in Metastasis, pp.197-219
Springer Netherlands
10/18/2011
DOI: 10.1007/978-94-007-2558-4_8
Abstract
Hematogenous metastasis involves the entry of cancer cells into the circulation at a primary tumor site and the extravasation of those cells at a secondary organ which may ultimately support the growth of a metastatic tumor. Although extravasation is likely an obligate step in metastasis, it is relatively poorly understood in part due the difficulty studying this process in appropriate experimental models in vivo. Thus, there remain open questions about how cancer cells interact with the vascular wall during this process including the extent to which non-selective mechanisms such as size restriction versus specific adhesive interactions determine the behavior of extravasating cancer cells; how cancer cells cross the endothelium; and the degree to which extravasation limits the overall efficiency of metastasis. The answers to these questions are influenced by specific properties of both the cancer cells and the nature of the vascular bed involved. In this Chapter, we review our current understanding of the cellular and molecular biology of cancer cell extravasation and discuss how this knowledge impacts clinical issues related to the biology of circulating tumor cells and cancer therapy.
Details
- Title: Subtitle
- Cellular and Molecular Biology of Cancer Cell Extravasation
- Creators
- J. Matthew Barnes - Roy J. and Lucille A. Carver College of MedicineMichael D. Henry - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Book chapter
- Publication Details
- Signaling Pathways and Molecular Mediators in Metastasis, pp.197-219
- DOI
- 10.1007/978-94-007-2558-4_8
- Publisher
- Springer Netherlands; Dordrecht
- Language
- English
- Date published
- 10/18/2011
- Academic Unit
- Molecular Physiology and Biophysics; Pathology; Radiation Oncology
- Record Identifier
- 9984302191902771
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