Book chapter
Cellular and Viral Mechanisms of HIV-1 Transmission Mediated by Dendritic Cells
HIV Interactions with Dendritic Cells, pp.109-130
Advances in Experimental Medicine and Biology, Springer New York
08/06/2012
DOI: 10.1007/978-1-4614-4433-6_4
PMCID: PMC3515677
PMID: 22975873
Abstract
Dendritic cells (DCs) play a key role in the initial infection and cell-to-cell transmission events that occur upon HIV-1 infection. DCs interact closely with CD4+ T cells, the main target of HIV-1 replication. HIV-1 challenged DCs and target CD4+ T cells form a virological synapse that allows highly efficient transmission of HIV-1 to the target CD4+ T cells, in the absence of productive HIV-1 replication in the DCs. Immature and subsets of mature DCs show distinct patterns of HIV-1 replication and cell-to-cell transmission, depending upon the maturation stimulus that is used. The cellular and viral mechanisms that promote formation of the virological synapse have been the subject of intense study and the most recent progress is discussed here. Characterizing the cellular and viral factors that affect DC-mediated cell-to-cell transmission of HIV-1 to CD4+ T cells is vitally important to understanding, and potentially blocking, the initial dissemination of HIV-1 in vivo.
Details
- Title: Subtitle
- Cellular and Viral Mechanisms of HIV-1 Transmission Mediated by Dendritic Cells
- Creators
- Christopher M Coleman - Department of Veterinary Biosciences, Center for Retrovirus Research, The Ohio State University, Columbus, USACorine St Gelais - Department of Veterinary Biosciences, Center for Retrovirus Research, The Ohio State University, Columbus, USALi Wu - Department of Microbial Infection and Immunity, Center for Retrovirus Research, The Ohio State University, Columbus, USA
- Resource Type
- Book chapter
- Publication Details
- HIV Interactions with Dendritic Cells, pp.109-130
- Series
- Advances in Experimental Medicine and Biology
- DOI
- 10.1007/978-1-4614-4433-6_4
- PMID
- 22975873
- PMCID
- PMC3515677
- NLM abbreviation
- Adv Exp Med Biol
- ISSN
- 0065-2598
- Publisher
- Springer New York; New York, NY
- Language
- English
- Date published
- 08/06/2012
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984002385702771
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