Book chapter
Cerebral Endothelium and Astrocytes Cooperate in Supplying Docosahexaenoic Acid to Neurons
Frontiers in Cerebral Vascular Biology, pp.229-233
Advances in Experimental Medicine and Biology, Springer US
1993
DOI: 10.1007/978-1-4615-2920-0_36
Abstract
Elongated, more highly polyunsaturated derivatives of linolenic acid, especially docosahexaenoic acid (DHA), accumulate in neurons of the brain (1). We have previously shown that neurons themselves are incapable of significant essential fatty acid elongation and desaturation and, thus, are dependent upon a supply of preformed DHA (2). However, astrocytes and cerebral endothelium actively elongate and desaturate the ω-3 fatty acid precursors, linolenic acid and eicosapentaenoic acid (EPA) (2, 3). By doing so they may together represent an important source of DHA for the central nervous system.
Details
- Title: Subtitle
- Cerebral Endothelium and Astrocytes Cooperate in Supplying Docosahexaenoic Acid to Neurons
- Creators
- Steven A Moore - University of Iowa
- Resource Type
- Book chapter
- Publication Details
- Frontiers in Cerebral Vascular Biology, pp.229-233
- Publisher
- Springer US; Boston, MA
- Series
- Advances in Experimental Medicine and Biology
- DOI
- 10.1007/978-1-4615-2920-0_36
- ISSN
- 0065-2598
- Language
- English
- Date published
- 1993
- Academic Unit
- Pathology
- Record Identifier
- 9984186526802771
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