Book chapter
Cerebral vascular function in genetically altered mice
The Blood-Brain Barrier, Vol.89, pp.505-512
Methods in molecular medicine, 89, Humana Press
2003
DOI: 10.1385/1-59259-419-0:505
PMID: 12958443
Abstract
Manipulation of genes in the mouse genome to produce transgenic or gene-targeted animals represents a powerful experimental tool to study the role of specific gene products in complex physiological systems. Because of the power of studying genetically altered mice, many laboratories have begun to incorporate the use of these models in studies of blood vessels including the cerebral circulation (1). Perhaps the biggest effort in this regard relates to studies of cerebral ischemia and mechanisms of brain injury and cell death. The present review will summarize methods and progress that has been made in studies of one aspect of vascular biology—vascular function in the carotid artery and cerebral circulation in mice.
Details
- Title: Subtitle
- Cerebral vascular function in genetically altered mice
- Creators
- Frank M Faraci - Cardiovascular Center, University of Iowa College of Medicine, Iowa City, IA, USA
- Resource Type
- Book chapter
- Publication Details
- The Blood-Brain Barrier, Vol.89, pp.505-512
- Publisher
- Humana Press; United States
- Series
- Methods in molecular medicine; 89
- DOI
- 10.1385/1-59259-419-0:505
- PMID
- 12958443
- ISSN
- 1543-1894
- eISSN
- 1940-6037
- Grant note
- HL-38901 / NHLBI NIH HHS HL-62984 / NHLBI NIH HHS NS-24621 / NINDS NIH HHS
- Language
- English
- Date published
- 2003
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040570002771
Metrics
28 Record Views