Book chapter
Chapter 1 - Historical and Clinical Overview: Implications for Schizophrenia Research
The Neurobiology of Schizophrenia, pp.3-13
Elsevier Inc
2016
DOI: 10.1016/B978-0-12-801829-3.00009-4
Abstract
Schizophrenia is not an etiologically defined disorder, but rather a syndrome. Diagnostic criteria of the two most widely used diagnostic systems, ICD-10 and DSM-V, are based on clinical symptoms and differ between them. Moreover, because of these two distinct classification systems, two patients can be diagnosed with schizophrenia even though they do not share a single symptom at the time of examination. This clinical heterogeneity poses serious challenges for the study of the neurobiological underpinnings of schizophrenia. In this introductory chapter, we briefly review historical definitions of schizophrenia and their influence on current diagnostic criteria. Therapeutic approaches, as well as basic research, have fueled new insight into the pathophysiology of the disorder. We also provide a short overview of the major developments in the history of neurobiological research of schizophrenia. Addressing the clinical heterogeneity found in schizophrenia will be a major challenge for future studies on the disorder.
Details
- Title: Subtitle
- Chapter 1 - Historical and Clinical Overview: Implications for Schizophrenia Research
- Creators
- T Nickl-Jockschat - Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, GermanyT Abel - Department of Biology, University of Pennsylvania, Philadelphia, PA, United States
- Resource Type
- Book chapter
- Publication Details
- The Neurobiology of Schizophrenia, pp.3-13
- DOI
- 10.1016/B978-0-12-801829-3.00009-4
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2016
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984070860002771
Metrics
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