Book chapter
Chapter 1 - Induced pluripotent stem cells: novel concepts for respiratory disease modeling
Novel Concepts in iPSC Disease Modeling, pp.1-58
Elsevier Inc
2022
DOI: 10.1016/B978-0-12-823882-0.00003-5
Abstract
The past decade has witnessed the advent of induced pluripotency and methodology to direct these pluripotent stem cells to differentiate into many tissue-specific cell types, including those comprising the respiratory epithelium. Induced pluripotent stem cell-derived, (iPSC-derived), airway cells have expanded our capacity to replicate both respiratory development and disease. These relevant and reproducible models provide options to study disease-specific changes occurring in humans, which rodent models often do not readily recapitulate. Not only do these models use human cells, but they can also be patient-specific or engineered to reflect precise disease-causing mutations in controlled and isogenic cellular systems. Such advances represent a new era of precision medicine approaches for the evaluation and treatment of respiratory disease. This chapter presents a summary of recent advances in the generation of iPSC-derived cells, and their use in modeling human respiratory disease.
Details
- Title: Subtitle
- Chapter 1 - Induced pluripotent stem cells: novel concepts for respiratory disease modeling
- Creators
- Ben A Calvert - Hastings CenterZareeb Lorenzana - Hastings CenterChristiana N. Senger - Hastings CenterChe-Yu Hsu - Hastings CenterShana N. Busch - Hastings CenterSinem Koc-Gunel - Hastings CenterErik J. Quiroz - University of Southern CaliforniaAmy L. Ryan - University of Southern California
- Resource Type
- Book chapter
- Publication Details
- Novel Concepts in iPSC Disease Modeling, pp.1-58
- DOI
- 10.1016/B978-0-12-823882-0.00003-5
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2022
- Academic Unit
- Anatomy and Cell Biology
- Record Identifier
- 9984284340102771
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