Book chapter
Chapter 10 - Characterization of trabecular bone plate–rod micro-architecture using skeletonization and digital topologic and geometric analysis
Skeletonization, pp.287-311
Elsevier Ltd
2017
DOI: 10.1016/B978-0-08-101291-8.00012-2
Abstract
Osteoporosis is an adult bone disease linked to increased risk of fragile fractures leading to substantial morbidity, mortality, and financial costs. Clinically, osteoporosis is defined by low bone mineral density (BMD); however, increasing evidence suggests that trabecular bone (TB) micro-architectural quality is an important determinant of bone strength and fracture-risk. In this chapter, we describe the role of skeletonization together with other digital topologic and geometric methods in characterizing trabecular plate–rod micro-architecture. In general, skeletonization serves two purposes in applications related to quantitative characterization of object morphology—provision of a compact representation of important object features and location of representative points for defining local structure morphology. Specifically, in this chapter, we present basic principles of skeletonization and its topological analysis characterizing local trabecular plate–rod distribution in a three-dimensional TB network, which is a quasi-random complex spongy object of plates and rods. This theory is further generalized using geodesic distance analysis and feature propagation for measurement of local trabecular plate-width and characterization of individual trabeculae on the continuum between a perfect plate and a perfect rod.
Details
- Title: Subtitle
- Chapter 10 - Characterization of trabecular bone plate–rod micro-architecture using skeletonization and digital topologic and geometric analysis
- Creators
- Punam K Saha - University of Iowa
- Resource Type
- Book chapter
- Publication Details
- Skeletonization, pp.287-311
- DOI
- 10.1016/B978-0-08-101291-8.00012-2
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 2017
- Academic Unit
- Radiology; Electrical and Computer Engineering
- Record Identifier
- 9984197070402771
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