Book chapter
Chapter 11 - Nanotechnology, mitochondria, and cancer: Mitochondria-targeting particles for biomedical applications
Mitochondrial Dysfunction and Nanotherapeutics, pp.291-310
Elsevier Inc
2021
DOI: 10.1016/B978-0-323-85666-9.00013-9
Abstract
Mitochondria have become a promising target for prevention and treatment of various diseases such as Alzheimer’s disease, Parkinson’s disease, ischemia-reperfusion injury, diabetes, obesity, and especially cancer. As a result, recent research has been focused on targeting mitochondria. To impact on mitochondrial functions, drug molecules need to be able to selectively travel to mitochondria and overcome barriers such as the cell membrane and mitochondrial membrane. This can be enhanced through various delivery systems which include liposomes, polymeric particles, and inorganic particles. These delivery systems are often decorated with mitochondriotropic moieties such as triphenylphosphonium and dequalinium. Here, we provide an overview of the various nanoparticle- and microparticle-based strategies used to deliver drugs to mitochondria.
Details
- Title: Subtitle
- Chapter 11 - Nanotechnology, mitochondria, and cancer: Mitochondria-targeting particles for biomedical applications
- Creators
- Amaraporn Wongrakpanich - Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, ThailandJiraphong Suksiriworapong - Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, ThailandSean M Geary - Division of Pharmaceutics and Translational Therapeutics, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United StatesPhawanan Sawangchan - Division of Pharmaceutics and Translational Therapeutics, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United StatesJanjira Intra - Amway Innovation & Science, Amway (Thailand) Ltd, Bangkok, ThailandUracha Ruktanonchai - National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency, Pathum Thani, ThailandAliasger K Salem - Division of Pharmaceutics and Translational Therapeutics, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United States
- Resource Type
- Book chapter
- Publication Details
- Mitochondrial Dysfunction and Nanotherapeutics, pp.291-310
- DOI
- 10.1016/B978-0-323-85666-9.00013-9
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering; Pharmaceutics
- Record Identifier
- 9984217432502771
Metrics
39 Record Views