Book chapter
Chapter 11 - Peripheral neuropathies
Neurobiology of Brain Disorders, pp.165-184
Elsevier Inc, Second Edition
2023
DOI: 10.1016/B978-0-323-85654-6.00006-X
Abstract
Disorders affecting the peripheral nerves are a common neurological problem. Peripheral neuropathies can be primary entities or a manifestation of several systemic illnesses, including diabetes, infections, vasculitis, neoplastic disorders, and vitamin deficiencies, or the consequence of toxins. In as many as 50% of patients, the mechanism responsible for the peripheral neuropathy remains elusive. From a biological standpoint, peripheral neuropathies are the clinical manifestation of dysfunction of peripheral axons and/or the Schwann cells that ensheathe them. Therefore, research in peripheral neuropathies has focused on understanding how peripheral axons (motor, sensory, and autonomic) develop and are maintained and how and why Schwann cells myelinate these axons. This chapter reviews the basic morphology and physiology of peripheral nerves, focusing on the peripheral axon and the myelin sheath, and describes the main conditions affecting these structures.
Details
- Title: Subtitle
- Chapter 11 - Peripheral neuropathies
- Creators
- Mario A. Saporta - University of MiamiAlexa Bacha - University of IowaMichael E. Shy - University of Iowa
- Resource Type
- Book chapter
- Publication Details
- Neurobiology of Brain Disorders, pp.165-184
- Edition
- Second Edition
- DOI
- 10.1016/B978-0-323-85654-6.00006-X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2023
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology
- Record Identifier
- 9984259244402771
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