Chapter 12 - Genetics and Genomics of Peripheral Arterial Disease

Ayotunde O. Dokun; Brian H. Annex

doi:10.1016/B978-0-12-801812-5.00007-X

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Book chapter

Chapter 12 - Genetics and Genomics of Peripheral Arterial Disease

Ayotunde O. Dokun and Brian H. Annex

Genomic and Precision Medicine, pp.197-219

Elsevier Inc, Third Edition

2018

DOI: 10.1016/B978-0-12-801812-5.00007-X

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Abstract

Advances in mouse and human genome research have dramatically altered the landscape and pace of advances in the diagnosis and treatment and many diseases. Peripheral arterial disease (PAD) is a major complication of systemic atherosclerosis and healthcare problem. Genetic and genomic research has done little to alter the diagnosis and management PAD, but this likely will change in the near future. This chapter will examine how rodent and human genetics in PAD may soon guide advances and eventually personalized therapies.

gene association studies

gene polymorphism

gene therapy

genome wide association studies

genomic methodology

haplotype

linkage disequilibrium

modifier gene

Peripheral arterial disease

quantitative trait locus

single nucleotide polymorphism

therapeutic angiogenesis

Details

Title: Subtitle: Chapter 12 - Genetics and Genomics of Peripheral Arterial Disease
Creators: Ayotunde O. Dokun - University of Virginia
Brian H. Annex - University of Virginia
Resource Type: Book chapter
Publication Details: Genomic and Precision Medicine, pp.197-219
Edition: Third Edition
DOI: 10.1016/B978-0-12-801812-5.00007-X
Publisher: Elsevier Inc
Language: English
Date published: 2018
Academic Unit: Molecular Physiology and Biophysics; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984297605402771

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