Book chapter
Chapter 13 - Epigenetic dysregulation in brain tumors and neurodevelopment
Neuropsychiatric Disorders and Epigenetics, pp.261-276
Elsevier Inc
2017
DOI: 10.1016/B978-0-12-800226-1.00013-7
Abstract
Epigenetics plays a well-known role in the regulation of stem cell identity, including the specification of cell lineages within the central nervous system, through a complex, regulated interplay between DNA methylation and the remodeling of chromatin. More recently, dysregulation of these mechanisms has been implicated in the pathobiology of brain tumors. Mutations in genes, such as H3F3A, ATRX, IDH, INI-1, and others cause global dysregulation of epigenetic signaling that leads to abnormal expression of oncogenes and inhibition of tumor suppressors, leading to disordered cell growth. Intriguingly, mutations in some of the same chromatin remodeling genes can lead to neurodevelopmental disorders or to brain tumors, depending on whether they are germline or somatic in origin. This has impelled new interest in understanding better the role of stem cells and various neural progenitors as putative tumor cells of origin in specific niches within the central nervous system.
Details
- Title: Subtitle
- Chapter 13 - Epigenetic dysregulation in brain tumors and neurodevelopment
- Creators
- M.M Hefti - Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesN Tsankova - Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Resource Type
- Book chapter
- Publication Details
- Neuropsychiatric Disorders and Epigenetics, pp.261-276
- DOI
- 10.1016/B978-0-12-800226-1.00013-7
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2017
- Academic Unit
- Pathology; Iowa Neuroscience Institute
- Record Identifier
- 9984070330402771
Metrics
19 Record Views