Book chapter
Chapter 13 - Protein Trafficking in the Exocytic Pathway of Polarized Epithelial Cells
Protein Trafficking in Neurons, pp.271-303
Elsevier Ltd
2007
DOI: 10.1016/B978-012369437-9/50020-7
Abstract
Like neurons, epithelial cells are highly polarized. A conspicuous feature of both cell types is the division of their surfaces into structurally and functionally distinct membrane domains—a lumen-facing apical domain and a basolateral domain—which contact neighboring cells and an underlying basal lamina. Separating apical and basolateral surfaces are tight junctions that help prevent passive mixing of proteins and lipids between the two domains and form a tight seal that regulates the transport of materials between cells in the epithelium. Maintenance of polarized membrane domains requires highly efficient sorting mechanisms that function in both the biosynthetic and the recycling pathways, as well as selective retention and removal mechanisms operating at each plasma membrane domain. Together, these mechanisms ensure that the correct proteins and lipids are delivered to and accumulate within the appropriate membrane domain. Epithelial cells provide a paradigm of cell polarization, and advances in the understanding of the fundamental mechanisms that underlie polarized trafficking in epithelial cells provide important clues about how these processes might function in neurons. This chapter focuses on how epithelial cells sort and deliver proteins to apical and basolateral surfaces and highlights similarities to mechanisms operating in neurons.
Details
- Title: Subtitle
- Chapter 13 - Protein Trafficking in the Exocytic Pathway of Polarized Epithelial Cells
- Creators
- Charles Yeaman - Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA, USA
- Resource Type
- Book chapter
- Publication Details
- Protein Trafficking in Neurons, pp.271-303
- DOI
- 10.1016/B978-012369437-9/50020-7
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 2007
- Academic Unit
- Anatomy and Cell Biology; Internal Medicine
- Record Identifier
- 9984025687702771
Metrics
34 Record Views