Chapter 17 - Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sézary Syndrome

Henry K Wong; Li Wu; Suresh de Silva; Pierluigi Porcu; Anjali Mishra

doi:10.1016/B978-0-12-800957-4.00017-5

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Book chapter

Chapter 17 - Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sézary Syndrome

Henry K Wong, Li Wu, Suresh de Silva, Pierluigi Porcu and Anjali Mishra

Epigenetics and Dermatology, pp.363-377

Elsevier Inc

2015

DOI: 10.1016/B978-0-12-800957-4.00017-5

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Abstract

Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common variants of cutaneous T-cell lymphomas (CTCLs) and generally have an indolent course. These are subtypes of a diverse group of lymphoid malignancies that develop in the skin, which includes both indolent and aggressive types. MF/SS are neoplasms of CD4+ T cells, expressing a memory effector phenotype. In the early stages, MF/SS can be challenging to differentiate from nonmalignant inflammatory skin disorders, such as psoriasis or nonspecific dermatitis and additional specific biomarkers would improve diagnosis. Gene expression analysis has uncovered many novel transcriptional abnormalities in MF/SS, hinting at epigenetic mechanisms potentially playing a role in the altered regulation. The mechanism for the epigenetic changes is unclear, but these abnormal genes may serve as biomarkers in MF/SS diagnosis, provide insight into the pathogenesis of MF/SS, and lead to new treatment approaches.

methylation

Sézary syndrome

mycosis fungoides

gene expression

Cutaneous T-cell lymphoma

Details

Title: Subtitle: Chapter 17 - Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sézary Syndrome
Creators: Henry K Wong - Comprehensive Cancer Center and Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio
Li Wu - Center for Retrovirology Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio
Suresh de Silva - Center for Retrovirology Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio
Pierluigi Porcu - Comprehensive Cancer Center and Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio
Anjali Mishra - Comprehensive Cancer Center and Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio
Resource Type: Book chapter
Publication Details: Epigenetics and Dermatology, pp.363-377
DOI: 10.1016/B978-0-12-800957-4.00017-5
Publisher: Elsevier Inc
Language: English
Date published: 2015
Academic Unit: Microbiology and Immunology
Record Identifier: 9984001226302771

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