Book chapter
Chapter 38 - The function and regulation of renal K+ channels
Seldin and Giebisch's The Kidney, pp.1383-1417
Academic Press, Sixth Edition
2026
DOI: 10.1016/B978-0-12-815389-5.00008-3
Abstract
Renal epithelial transport depends on the coordinated function of potassium channels with ion transporters (cotransporters, channels, and exchangers) and ion pumps in apical and basolateral membranes of distinct cell types along the nephron of the mammalian kidney. Potassium (K+) channels are key members of this integrated transport system in renal epithelial cells. Fig. 38.1 is a scheme providing an overview of the role of K+ channels in different renal segments. First, renal K+ channels participate in generating the cell membrane potential along the nephron segments. Since numerous transport processes in different nephron segments are electrogenic, changes in cell membrane potential could alter the transport rate of a given substance. Second, renal K+ channels are involved in the volume regulation that is essential for preventing cell swelling or shrinking in the hypotonic or hypertonic environment. Third, renal K+ channels play an important role in K+ recycling, which is essential for maintaining the function of several transport proteins such as Na+-K+-ATPase. Finally, renal K+ channels are extremely involved in K+ secretion in the aldosterone-sensitive distal nephron (ASDN).
Details
- Title: Subtitle
- Chapter 38 - The function and regulation of renal K+ channels
- Creators
- Wenhui Wang - New York Medical CollegeChou-Long Huang - University of Iowa
- Resource Type
- Book chapter
- Publication Details
- Seldin and Giebisch's The Kidney, pp.1383-1417
- Edition
- Sixth Edition
- DOI
- 10.1016/B978-0-12-815389-5.00008-3
- Publisher
- Academic Press; Amsterdam
- Language
- English
- Date published
- 2026
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9985161441102771
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