Book chapter
Chapter 4 - Stromal tumors: Exploring rare ovarian cancer types
Ovarian Cancer, pp.83-116
Elsevier
2025
DOI: 10.1016/B978-0-443-33536-5.00013-4
Abstract
Ovarian sex cord–stromal tumors (SCSTs) are a rare and heterogeneous group of ovarian neoplasms originating from either stromal cells or sex cords. They account for about 7% of all ovarian tumors and display a wide range of clinical, pathological, and molecular characteristics. They may develop at any age but are most frequently diagnosed in women of reproductive age. Clinical manifestations typically include pelvic mass, abdominal pain, and hormonal disturbances. SCSTs have a wide range of morphological patterns, such as granulosa cell tumors, fibromas, thecomas, and Sertoli cell tumors. Usually, various imaging techniques and clinical characteristics are cornerstones for diagnosing ovarian SCSTs. Most SCST patients have a good prognosis, particularly with early detection and appropriate management, but long-term monitoring is essential due to the risk of recurrences. The pathogenesis of SCSTs is often driven by mutations in genes such as FOXL2 and DICER1, among others. Surgical intervention remains the mainstay treatment, with various options including chemotherapy, radiotherapy, and hormonal therapies depending on the individual case. For younger patients desiring fertility preservation, fertility-sparing surgical techniques are employed. This chapter strives to comprehensively elucidate the clinical, pathological, and molecular profiles of SCSTs. It delves into diagnostic tools, treatment challenges, case reports, recent and ongoing clinical studies, and prospective advancements in the management of these tumors.
Details
- Title: Subtitle
- Chapter 4 - Stromal tumors: Exploring rare ovarian cancer types
- Creators
- Rajsi V. Parikh - B.J. Medical CollegeDisha V. Pandya - B.J. Medical CollegeShelly Bhatt - B.J. Medical CollegeMehul R. Chorawala - B.J. Medical CollegeRakesh B. Patel - University of Iowa, Internal MedicineBhupendra G. Prajapati - Ganpat UniversityPalak A. Shah - Department of Pharmacology and Pharmacy Practice, K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India
- Resource Type
- Book chapter
- Publication Details
- Ovarian Cancer, pp.83-116
- DOI
- 10.1016/B978-0-443-33536-5.00013-4
- Publisher
- Elsevier; Amsterdam, Netherlands
- Language
- English
- Date published
- 2025
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985132189302771
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