Book chapter
Chapter 4 Metabolic Transformations of Alkaloids
The Alkaloids: Chemistry and Pharmacology, pp.323-405
Elsevier Science & Technology
1987
DOI: 10.1016/S0099-9598(08)60310-7
Abstract
The alkaloids are an enormously complex grouping of nitrogen-containing organic compounds that are widespread in their natural occurrence and found in plants, mammals, arthropods, marine species, club mosses, fungi, and bacteria. This chapter presents the metabolism of alkaloids by microbial, mammalian, and plant metabolic systems; biotransformation reactions in a microbial or enzymatic system; and focuses on both the fascinating chemical and biochemical mechanisms of alkaloid biotransformation reactions—and on the metabolic systems that catalyze them. Microorganisms, plants, and mammalian systems all contain enzymes capable of catalyzing chemical transformations with alkaloid substrates. Interesting and useful enzyme reactions that may occur with alkaloids include oxidations, reductions, hydrolyses, and conjugation reactions. Monooxygenase activation and introduction of molecular oxygen may result in the formation of carbinolamine, which serves as a branch point in the generation of products. Biocatalysis with alkaloids affords rich opportunities for displaying novel biochemical reactions or unusual rearrangements that contribute to understanding of biosynthetic or biodegradative pathways.
Details
- Title: Subtitle
- Chapter 4 Metabolic Transformations of Alkaloids
- Creators
- J.P.N. Rosazza - University of IowaM.W. Duffel - University of Iowa
- Resource Type
- Book chapter
- Publication Details
- The Alkaloids: Chemistry and Pharmacology, pp.323-405
- Publisher
- Elsevier Science & Technology
- DOI
- 10.1016/S0099-9598(08)60310-7
- ISSN
- 0099-9598
- Language
- English
- Date published
- 1987
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Pharmacy; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984303161502771
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