Book chapter
Chapter 43 - Intracellular pH homeostasis
Seldin and Giebisch's The Kidney, pp.1561-1668
Academic Press, Sixth Edition
2026
DOI: 10.1016/B978-0-12-815389-5.00077-0
Abstract
We shall first consider the methodologies available for making pHi measurements and then examine the factors that contribute to changes in pHi: the thermodynamic forces acting on hydrogen ions (H+) and other charged acids/bases; the permeation of the cell membrane by electrically neutral acids and bases; the buffering power of the intracellular fluid (ICF); and transporters that regulate pHi by moving H+, bicarbonate ions (HCO3–) and/or other weak acid/bases across the plasma membrane. Because space does not permit us to summarize the vast array of acid-base transporters, we will focus on those that play a major role in pHi homeostasis. Emerging from this discussion will be a model of pHi regulation. Finally, in light of this model, we will consider several factors that fundamentally alter pHi homeostasis: alterations in pHo; temperature changes; metabolic inhibitors and hypoxia; cell shrinkage; hormones, growth factors, and oncogenes, including cancer.
Details
- Title: Subtitle
- Chapter 43 - Intracellular pH homeostasis
- Creators
- Ian M. Thornell - University of IowaMarie Michenkova - Virginia Commonwealth UniversitySara Taki - Case Western Reserve UniversityMark O. Bevensee - University of Alabama at BirminghamWalter F. Boron - Case Western Reserve University
- Resource Type
- Book chapter
- Publication Details
- Seldin and Giebisch's The Kidney, pp.1561-1668
- Edition
- Sixth Edition
- DOI
- 10.1016/B978-0-12-815389-5.00077-0
- Publisher
- Academic Press; Amsterdam
- Language
- English
- Date published
- 2026
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9985163541602771
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