Book chapter
Chapter 5 - Ovarian oncosomes
Ovarian Cancer, pp.117-172
Elsevier Inc
2025
DOI: 10.1016/B978-0-443-33536-5.00012-2
Abstract
Oncosomes, a distinct class of extracellular vesicles, are released by cancerous cells and are essential in the progression of various malignancies, including ovarian cancer. Their involvement in cellular communication inside the microenvironment of the tumor, tumor progression, and therapeutic resistance makes them a critical area of investigation. This chapter aims to investigate the molecular makeup, biogenesis, and functional significance of oncosomes in ovarian cancer. Additionally, it assesses the tactics for targeting oncosomes as a novel therapeutic strategy and looks at their potential as biomarkers for monitoring diagnosis and therapy. A thorough assessment of the most recent research was done to gauge our present knowledge on ovarian oncosomes, including their biogenesis, molecular cargo (proteins, lipids, RNA), and their impact on ovarian cancer progression. Clinical and preclinical studies focusing on oncosomes-targeted therapies and biomarker potential were also analyzed. Ovarian oncosomes are found to significantly influence tumor behavior, including promoting metastasis, immune modulation, and drug resistance. Their molecular cargo mirrors the oncogenic status of the tumor, making them promising candidates for liquid biopsy in ovarian cancer. Studies suggest that targeting oncosomes production or function may reduce tumor growth and overcome drug resistance. In a nutshell, ovarian oncosomes represent a promising frontier in ovarian cancer research, with implications for both diagnostics and therapeutics. Targeting oncosomes offers potential for novel therapeutic strategies, which could enhance the effectiveness of current treatments and improve patient outcomes. Further research is needed to better understand their clinical applications and fully integrate them into precision medicine.
Details
- Title: Subtitle
- Chapter 5 - Ovarian oncosomes
- Creators
- Namrata B. Parmar - B.J. Medical CollegeManya D. Desai - Department of Pharmacology and Pharmacy Practice, L. M. College of Pharmacy, Ahmedabad, Gujarat, IndiaPriyajeet S. Parekh - Bridge PharmaRakesh B. Patel - University of Iowa, Internal MedicineDisha D. Shah - B.J. Medical CollegeMehul R. Chorawala - B.J. Medical CollegePalak A. Shah - Department of Pharmacology and Pharmacy Practice, K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, IndiaBhupendra, G. Prajapati - Parul University
- Resource Type
- Book chapter
- Publication Details
- Ovarian Cancer, pp.117-172
- DOI
- 10.1016/B978-0-443-33536-5.00012-2
- Publisher
- Elsevier Inc; Amsterdam, Netherlands
- Language
- English
- Date published
- 2025
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985132187902771
Metrics
1 Record Views