Book chapter
Chapter 52 - Articular cartilage injury
Principles of Tissue Engineering, pp.967-977
Elsevier Inc, Fifth Edition
2020
DOI: 10.1016/B978-0-12-818422-6.00054-X
Abstract
In an effort to decrease the risk of posttraumatic osteoarthritis (OA), the form of OA that develops following joint injuries, surgeons and scientists have been seeking ways to prevent progressive joint degeneration following joint injury or to restore damaged articular cartilage. Recent experimental studies have shown that preventing chondrocyte mitochondrial dysfunction following joint injuries has the potential to prevent posttraumatic OA. Surgeons have used operative treatments, including penetrating subchondral bone, soft-tissue grafts, and cell transplants, to stimulate restoration of damaged articular surfaces, with variable results. This chapter covers recent advances in understanding of how joint injuries lead to OA by causing chondrocyte mitochondrial dysfunction and the use of artificial matrices, growth factors, and immature chondrocytes or stem cells to promote cartilage repair as well as work suggesting that several agents, including caspase inhibitors, antioxidants, and antiinflammatory drugs may minimize the risk or severity of OA following joint injuries.
Details
- Title: Subtitle
- Chapter 52 - Articular cartilage injury
- Creators
- J.A. MartinM. ColemanJ.A. Buckwalter
- Resource Type
- Book chapter
- Publication Details
- Principles of Tissue Engineering, pp.967-977
- Edition
- Fifth Edition
- DOI
- 10.1016/B978-0-12-818422-6.00054-X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Orthopedics and Rehabilitation; Radiation Oncology; Injury Prevention Research Center
- Record Identifier
- 9984304710602771
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