Book chapter
Chapter 6 - Exploring Neurogenomics of Schizophrenia With Allen Institute for Brain Science Resources
The Neurobiology of Schizophrenia, pp.83-106
Elsevier Inc
2016
DOI: 10.1016/B978-0-12-801829-3.00014-8
Abstract
Schizophrenia is highly heritable, and genetic risk for vulnerability is conferred by a large number of alleles, including common alleles of small effect that have been detected through genome-wide association. Because the public health impact of schizophrenia is so substantial, data and tools to further our study of this complex disease are needed. The Allen Brain Atlas (www.brain-map.org) is an online, publicly available resource that integrates gene expression and connectivity data with neuroanatomical information for mouse, human, and nonhuman primate, and it may be of interest to researchers working in these areas. As one of the most comprehensive gene expression resources for the nervous system, scientists regularly use these data to learn about the expression profile of genes in various neuroanatomical regions. Additional uses include searching for biomarkers, correlating gene expression to anatomy, and other large-scale correlative data analysis. This chapter reviews the resources available and describes how certain ones may be of use to those studying schizophrenia.
Details
- Title: Subtitle
- Chapter 6 - Exploring Neurogenomics of Schizophrenia With Allen Institute for Brain Science Resources
- Creators
- M Hawrylycz - Allen Institute for Brain Science, Seattle, WA, United StatesT Nickl-Jockschat - Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, GermanyS Sunkin - Allen Institute for Brain Science, Seattle, WA, United States
- Resource Type
- Book chapter
- Publication Details
- The Neurobiology of Schizophrenia, pp.83-106
- DOI
- 10.1016/B978-0-12-801829-3.00014-8
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2016
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984070535602771
Metrics
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