Book chapter
Chapter 6 Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase
Progress in Brain Research, pp.97-115
Elsevier Science & Technology
2008
DOI: 10.1016/S0079-6123(07)00006-4
PMCID: PMC2914307
PMID: 18394470
Abstract
The hippocampus is crucial for the consolidation of new declarative long-term memories. Genetic and behavioral experimentation have revealed that several protein kinases are critical for the formation of hippocampus-dependent long-term memories. Cyclic-AMP dependent protein kinase (PKA) is a serine–threonine kinase that has been strongly implicated in the expression of specific forms of hippocampus-dependent memory. We review evidence that PKA is required for hippocampus-dependent memory in mammals, and we highlight some of the proteins that have been implicated as targets of PKA. Future directions and open questions regarding the role of PKA in memory storage are also described.
Details
- Title: Subtitle
- Chapter 6 Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase
- Creators
- Ted Abel - University of Pennsylvania, Department of Biology, Biological Basis of Behavior Program, Philadelphia, PA 19104, USAPeter V Nguyen - University of Alberta School of Medicine, Departments of Physiology and Psychiatry, Centre for Neuroscience, Edmonton, AB T6G 2H7, Canada
- Resource Type
- Book chapter
- Publication Details
- Progress in Brain Research, pp.97-115
- DOI
- 10.1016/S0079-6123(07)00006-4
- PMID
- 18394470
- PMCID
- PMC2914307
- NLM abbreviation
- Prog Brain Res
- eISSN
- 1875-7855
- ISSN
- 0079-6123
- Publisher
- Elsevier Science & Technology
- Language
- English
- Date published
- 2008
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065738702771
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