Book chapter
Chapter 61 - A Graphical Method of Determining Tracer Influx Constants in the Presence of Labeled Metabolites
Quantification of Brain Function Using PET, pp.312-316
Academic Press
1996
DOI: 10.1016/B978-012389760-2/50063-3
Abstract
The graphical analysis technique of Patlak, Blasburg, and Fenstermacher and Gjedde is a popular tool for estimating blood-to-tissue influx constants from multiple-time uptake data. This chapter presents a convenient extension of this technique that can be applied to tracers with significant quantities of labeled metabolites in the blood, which cause errors in the standard graphical analysis. The extended graphical method applies when the intact tracer is irreversibly trapped in tissue and the labeled metabolites are not. It has been concluded that the extended graphical analysis approach provides a simple and efficient method for estimating tissue transfer constants for tracers with labeled metabolites.
Details
- Title: Subtitle
- Chapter 61 - A Graphical Method of Determining Tracer Influx Constants in the Presence of Labeled Metabolites
- Creators
- David A. Mankoff - Division of Nuclear Medicine, University of Washington, Seattle, Washington 98195Michael M. Graham - University of WashingtonAnthony F. Shields - Department of Medicine and Veterans Affairs Medical Center and University of Washington, Seattle, Washington
- Resource Type
- Book chapter
- Publication Details
- Quantification of Brain Function Using PET, pp.312-316
- DOI
- 10.1016/B978-012389760-2/50063-3
- Publisher
- Academic Press
- Language
- English
- Date published
- 1996
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984315648302771
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