Chapter 68 - SUDEP Animal Models

Alica M Goldman; Gordon Buchanan; Isamu Aiba; Jeffrey L Noebels

doi:10.1016/B978-0-12-804066-9.00070-5

Back

Book chapter

Chapter 68 - SUDEP Animal Models

Alica M Goldman, Gordon Buchanan, Isamu Aiba and Jeffrey L Noebels

Models of Seizures and Epilepsy, pp.1007-1018

Elsevier Inc, Second Edition

2017

DOI: 10.1016/B978-0-12-804066-9.00070-5

View Online

Abstract

Sudden unexpected death in epilepsy (SUDEP) is the most common cause of epilepsy related mortality and animal models have collectively helped elucidate SUDEP causes and mechanisms. The chapter aims to serve as general resource and a summary of the current state of monitoring approaches commonly used in animals engineered or manipulated to model physiological processes relevant to SUDEP. One has to bear in mind that there are many variations of methods aimed at measuring and analyzing cortical, cardio-autonomic, and respiratory activities and the approach is typically driven by the research questions, type of animal model type, as well as by cost, availability or access to a specialized experimental set up.

epilepsy

sleep

sudden death

spreading depression

cardiac arrhythmia

autonomic function

respiration

monitoring

plethysmography

Details

Title: Subtitle: Chapter 68 - SUDEP Animal Models
Creators: Alica M Goldman - Baylor College of Medicine, Houston, TX, United States
Gordon Buchanan - University of Iowa, Iowa City, IA, United States
Isamu Aiba - Baylor College of Medicine, Houston, TX, United States
Jeffrey L Noebels - Baylor College of Medicine, Houston, TX, United States
Resource Type: Book chapter
Publication Details: Models of Seizures and Epilepsy, pp.1007-1018
Edition: Second Edition
DOI: 10.1016/B978-0-12-804066-9.00070-5
Publisher: Elsevier Inc
Language: English
Date published: 2017
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984070415002771

Metrics

68 Record Views

10 Times Cited - Web of Science