Book chapter
Chapter 7 - Cerebral Vascular Muscle
Primer on Cerebrovascular Diseases, pp.42-47
Elsevier Inc, Second Edition
2017
DOI: 10.1016/B978-0-12-803058-5.00007-2
Abstract
Regulation of cerebral blood flow (CBF) is determined mainly by changes in diameter of resistance vessels in brain. The moment-to-moment changes in vessel diameter are primarily the function of vascular muscle. Vascular muscle receives, integrates, and responds to mechanical forces as well as signals from other cell types. In this chapter, we summarize some recent advances regarding the regulation of vascular tone in cerebral arteries and the microcirculation. We discuss myogenic tone and myogenic reactivity in the context of autoregulation, along with the impact of transient receptor potential channels. Major mechanisms of vasodilation are presented including the nitric oxide system, the impact of potassium channels, and effects of reactive oxygen species. Lastly, as proof of principle, we discuss the pathobiology of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy as an example of how a functional defect in vascular muscle can adversely affect CBF with resulting effects on brain function.
Details
- Title: Subtitle
- Chapter 7 - Cerebral Vascular Muscle
- Creators
- T.M. De Silva - Monash UniversityF.M. Faraci - University of Iowa
- Resource Type
- Book chapter
- Publication Details
- Primer on Cerebrovascular Diseases, pp.42-47
- Edition
- Second Edition
- DOI
- 10.1016/B978-0-12-803058-5.00007-2
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2017
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984303857502771
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