Chapter 7 - Engineering the Surface of Cells Using Biotin–Avidin Chemistry

Kawther K Ahmed; Sean M Geary; Aliasger K Salem

doi:10.1016/B978-1-4557-3146-6.00007-6

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Book chapter

Chapter 7 - Engineering the Surface of Cells Using Biotin–Avidin Chemistry

Kawther K Ahmed, Sean M Geary and Aliasger K Salem

Micro- and Nanoengineering of the Cell Surface, pp.143-155

Elsevier Inc

2014

DOI: 10.1016/B978-1-4557-3146-6.00007-6

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Abstract

This chapter is dedicated to the use of biotin-avidin chemistry to functionalize cell surfaces for a range of biomedical and biotechnological applications. The importance of different avidin analogs and methods of cell surface biotinylation are discussed. The valuable role of biotin-avidin chemistry in augmenting tissue engineering is highlighted as well as its role in generating cell-particle hybrids for downstream medical purposes such as cancer vaccines and targeted drug delivery.

Avidin

Biotin

Biotinylation

Cell surface modification

Noncovalent binding

streptavidin

Tissue engineering

Details

Title: Subtitle: Chapter 7 - Engineering the Surface of Cells Using Biotin–Avidin Chemistry
Creators: Kawther K Ahmed
Sean M Geary
Aliasger K Salem
Resource Type: Book chapter
Publication Details: Micro- and Nanoengineering of the Cell Surface, pp.143-155
DOI: 10.1016/B978-1-4557-3146-6.00007-6
Publisher: Elsevier Inc
Language: English
Date published: 2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering
Record Identifier: 9984216727902771

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