Book chapter
Chapter 71 - Counts vs. Flow: When Does It Matter?
Quantification of Brain Function Using PET, pp.365-371
Academic Press
1996
DOI: 10.1016/B978-012389760-2/50073-6
Abstract
In this chapter, region of interest (ROI) methods are evaluated along with function of interest (FOI) methods to determine when and if quantitative flow values (arterial input function required) provide different or better information over normalized image data when similar strategies were employed for analyzing each of the data types (counts vs. flow images). In this method ten normal right-handed volunteers were studied with [15O]water and positron emission tomography (PET) imaging during simultaneous presentation of auditory and visual stimulation paradigms. Arterial blood sampling was performed over the image acquisition period. PET count and absolute flow images were created. The FOI approach resulted in similar patterns of activation from the normalized count, normalized flow, or absolute flow data. To achieve equivalent results from the ROI count or flow data, respective normalization by mean global count or flow is required. If only normalized FOI analyses are applied, arterial blood data and absolute flow calculations are not needed. To measure changes in global flow, absolute flow data is necessary.
Details
- Title: Subtitle
- Chapter 71 - Counts vs. Flow: When Does It Matter?
- Creators
- Richard D Hichwa - P.E.T. Imaging Center, Department of RadiologyDaniel S O'Leary - Department of PsychiatryLaura L Boles Ponto - P.E.T. Imaging Center, Department of RadiologyStephan Arndt - Department of PsychiatryTed Cizadlo - Department of PsychiatryRichard R Hurtig - Department of Speech, Pathology and Audiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242G. Leonard Watkins - P.E.T. Imaging Center, Department of RadiologyScott D Wollenweber - P.E.T. Imaging Center, Department of RadiologyNancy C Andreasen - Department of Psychiatry
- Resource Type
- Book chapter
- Publication Details
- Quantification of Brain Function Using PET, pp.365-371
- DOI
- 10.1016/B978-012389760-2/50073-6
- Publisher
- Academic Press
- Language
- English
- Date published
- 1996
- Academic Unit
- Radiology; Communication Sciences and Disorders; Psychiatry; Research Administration; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics; Physics and Astronomy; Radiation Oncology; Nursing; Injury Prevention Research Center
- Record Identifier
- 9984068341702771
Metrics
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