Book chapter
Chapter 75 - A Comparison of Approaches to the Statistical Analysis of Cognitive Activation Studies Using [15O]H2O with Positron Emission Tomography
Quantification of Brain Function Using PET, pp.389,V-392,V
Academic Press
1996
DOI: 10.1016/B978-012389760-2/50077-3
Abstract
The use of [15O]H2O to study human cognition and emotion has given neuropsychiatrists a powerful tool for measuring and understanding brain function. As the “water method” has matured, sophisticated techniques for conducting statistical analysis of data have been developed. This chapter compares two of the most widely used techniques: the Friston method (SPM94) and the Worsley method (Montreal). Both methods are applied to a single data set of 33 subjects, who have been studied in a paradigm designed to evaluate memory for word lists to determine the comparability of the two methods in the world of “real data.” One subtraction from this study was compared: long-term memory for words minus reading words. The computer program SPM94 implemented the method developed by Friston and colleague. Aspects of the analysis are held constant so that differences in statistical methods could be cleanly contrasted. The methods' location of peaks, volume of peaks, and size of t or z statistic characterizing the peak are also compared. In conclusion, both methods are found to produce generally similar results identifying brain regions active during long-term memory: frontal parietal, cingulate, and cerebellar.
Details
- Title: Subtitle
- Chapter 75 - A Comparison of Approaches to the Statistical Analysis of Cognitive Activation Studies Using [15O]H2O with Positron Emission Tomography
- Creators
- Stephan Arndt - The Mental Health Clinical Research Center, Department of PsychiatryTed Cizadlo - The Mental Health Clinical Research Center, Department of PsychiatryNancy C Andreasen - The Mental Health Clinical Research Center, Department of PsychiatryGene Zeien - The Mental Health Clinical Research Center, Department of PsychiatryGreg Harris - The Mental Health Clinical Research Center, Department of PsychiatryDaniel S O'Leary - The Mental Health Clinical Research Center, Department of PsychiatryG. Leonard Watkins - PET Imaging Center, Department of Radiology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242Laura L Boles Ponto - PET Imaging Center, Department of Radiology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242Richard D Hichwa - PET Imaging Center, Department of Radiology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242
- Resource Type
- Book chapter
- Publication Details
- Quantification of Brain Function Using PET, pp.389,V-392,V
- DOI
- 10.1016/B978-012389760-2/50077-3
- Publisher
- Academic Press
- Language
- English
- Date published
- 1996
- Academic Unit
- Radiology; Psychiatry; Research Administration; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics; Physics and Astronomy; Radiation Oncology; Nursing; Injury Prevention Research Center
- Record Identifier
- 9984068232702771
Metrics
23 Record Views