Chapter Nine - Microparticles and Nanoparticles for Cancer-Targeting Vaccines

A.S Morris; A Wongrakpanich; S.M Geary; A.K Salem

doi:10.1016/B978-0-323-39981-4.00009-9

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Book chapter

Chapter Nine - Microparticles and Nanoparticles for Cancer-Targeting Vaccines

A.S Morris, A Wongrakpanich, S.M Geary and A.K Salem

Micro- and Nanotechnology in Vaccine Development, pp.171-183

Elsevier Inc

2017

DOI: 10.1016/B978-0-323-39981-4.00009-9

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Abstract

Cancer vaccines need to promote robust cellular tumor-specific immune responses capable of overcoming the immunosuppressive microenvironments within the cancer patient if they are to exhibit therapeutic benefit. Biodegradable polymer-based microparticles (MPs) and nanoparticles (NPs) offer the opportunity to contribute to the stimulation of such responses, and they also possess important advantages over many other vaccine modalities in terms of tunability and safety. This chapter focuses on MP- and NP-based delivery systems for cancer vaccines, beginning with a brief introduction into polymer-based delivery of antigens and adjuvants. Emphasis will be placed on the parameters (eg, size, type of adjuvant) that influence the magnitude and type of immune response generated by MP and NP vaccines as well as elaborating on the motivation for codelivering antigens and adjuvants together rather than separately. Preclinical studies using MP and NP formulations for novel cancer vaccine delivery systems will be discussed.

adjuvant

antigen

cancer vaccine

CpG

microparticles

nanoparticles

PLGA

polylactic-co-glycolic acid

Details

Title: Subtitle: Chapter Nine - Microparticles and Nanoparticles for Cancer-Targeting Vaccines
Creators: A.S Morris - Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United States
A Wongrakpanich - Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
S.M Geary - Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United States
A.K Salem - Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United States
Resource Type: Book chapter
Publication Details: Micro- and Nanotechnology in Vaccine Development, pp.171-183
DOI: 10.1016/B978-0-323-39981-4.00009-9
Publisher: Elsevier Inc
Language: English
Date published: 2017
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering
Record Identifier: 9984216584302771

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