Book chapter
Chapter Six - Tumor-on-a-chip devices for cancer immunotherapy
Engineering Technologies and Clinical Translation, pp.155-195
Elsevier Inc
2022
DOI: 10.1016/B978-0-323-90949-5.00006-1
Abstract
This chapter introduces a range of microfluidics-based approaches to the manipulation of immune cells and the recapitulation of the tumor microenvironment, i.e., Tumor-on-a-Chip, for elucidating the mechanism of immune surveillance and for advancing cancer immunotherapy. This chapter starts with a brief introduction of microfluidics created by the use of advanced microfabrication, as well as unique flow phenomena at the microscale, such as laminar flow and droplets. Tumor-on-a-chip models and approaches have demonstrated unprecedented capability to reconstruct and exploit essential tumor features and to produce and screen therapeutic immune cells and compounds in an efficient and high(er)-throughput manner. In particular, Tumor-on-chips enable the recapitulation of key complex and tissue-level tumor features, such as vascularization and extravasation, which are usually challenging for conventional in vitro methods. Tumor-on-chips represent a set of powerful and versatile engineering tools that hold promise for meeting diverse needs of advancing cancer immunotherapy.
Details
- Title: Subtitle
- Chapter Six - Tumor-on-a-chip devices for cancer immunotherapy
- Creators
- Xuan MuYu Shrike Zhang
- Resource Type
- Book chapter
- Publication Details
- Engineering Technologies and Clinical Translation, pp.155-195
- DOI
- 10.1016/B978-0-323-90949-5.00006-1
- Publisher
- Elsevier Inc
- Language
- English
- Electronic publication date
- 09/03/2021
- Date published
- 2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984304559002771
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