Book chapter
Chronic Myeloproliferative Neoplasms (Other Than Chronic Myeloid Leukemia)
Practical Lymph Node and Bone Marrow Pathology, pp.517-530
Practical Anatomic Pathology, Springer International Publishing
03/29/2020
DOI: 10.1007/978-3-030-32189-5_23
Abstract
The myeloproliferative neoplasms (MPNs) are a group of leukemias that result from clonal expansion of one or more myeloid lineage cells. This clonal expansion is due to mutant tyrosine kinases or mutated downstream proteins. The related molecular drivers cause overlapping pathological, laboratory, and clinical presentations. Some MPNs share oncogenic driver mutations, while others are defined by specific translocations. The accurate diagnosis has prognostic and therapeutic implications and requires close correlation with pathological, clinical, and laboratory data. Most MPNs are initially indolent with effective hematopoiesis early in the course of disease; however, they typically progress to an acute leukemia, a marrow failure due to myelofibrosis, or a myelodysplastic syndrome. This leads to a wide variation of morphologic appearances for the pathologist depending on when in the patient’s natural course of disease the sample crosses the microscope stage.
Details
- Title: Subtitle
- Chronic Myeloproliferative Neoplasms (Other Than Chronic Myeloid Leukemia)
- Creators
- Matthew E Keeney - University of Iowa Hospitals and ClinicsSharathkumar Bhagavathi - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Book chapter
- Publication Details
- Practical Lymph Node and Bone Marrow Pathology, pp.517-530
- Series
- Practical Anatomic Pathology
- DOI
- 10.1007/978-3-030-32189-5_23
- Publisher
- Springer International Publishing; Cham
- Language
- English
- Date published
- 03/29/2020
- Academic Unit
- Pathology
- Record Identifier
- 9984200022902771
Metrics
29 Record Views