Book chapter
Chronic Recurrent Multifocal Osteomyelitis and Related Disorders
Handbook of Systemic Autoimmune Diseases, pp.315-339
Elsevier Science & Technology
2016
DOI: 10.1016/B978-0-444-63596-9.00015-3
Abstract
The innate immune system, and in particular dysregulation of the interleukin-1 (IL-1) pathway, plays a central role in the pathogenesis of many pediatric rheumatic disorders that are broadly classified as autoinflammatory disorders. Many of these disorders have a genetic etiology and despite affecting a few key immunologic pathways, distinct patterns of tissue specificity have emerged. Chronic recurrent multifocal osteomyelitis (CRMO, also called chronic nonbacterial osteomyelitis) is the most common autoinflammatory disorder that targets the bone. Recent advances in the understanding of CRMO have led to the identification of disease-associated genes (LPIN2, Pstpip2, IL1RN), cytokine dysregulation including the importance of IL-1 in bone inflammation, and the intriguing finding that diet can prevent inflammation of the bone in a murine model of the disease.
Details
- Title: Subtitle
- Chronic Recurrent Multifocal Osteomyelitis and Related Disorders
- Creators
- P.J Ferguson - University of Iowa Carver College of Medicine, Iowa City, IA, United States
- Resource Type
- Book chapter
- Publication Details
- Handbook of Systemic Autoimmune Diseases, pp.315-339
- Publisher
- Elsevier Science & Technology
- DOI
- 10.1016/B978-0-444-63596-9.00015-3
- ISSN
- 1571-5078
- Language
- English
- Date published
- 2016
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Rheumatology, Allergy, and Immunology
- Record Identifier
- 9984070692402771
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