Book chapter
Clinical Pharmacogenetics
Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, pp.803-821
Cancer Drug Discovery and Development, Humana Press, Second edition
2014
DOI: 10.1007/978-1-4614-9135-4_40
Abstract
Pharmacogenetics in clinical medicine is an emerging field that has seen significant progress in the past decade, with the implementation of new clinical guidelines recommending routine testing of specific genes that have good predictive potential. This chapter describes the current understanding of clinical pharmacogenetics, some of the problems and challenges faced in development and execution, and the key requirements in order to make it an integral part of translational research. This section also lists the valid biomarkers associated with drugs used to treat solid tumors and hematological malignancies and describes their use in clinical practice. It illustrates the clinical impact of genetic polymorphisms on drug disposition and of drug target genes on the pharmacotherapy of patients with these conditions. Finally, this section outlines pharmacogenetic strategies for drug selection that aid in therapeutic optimization.
Details
- Title: Subtitle
- Clinical Pharmacogenetics
- Creators
- Kamakshi Sachidanandam - University of Wisconsin–MadisonJill M. Kolesar - University of Wisconsin–Madison
- Contributors
- William D. Figg (Editor)Howard L McLeod (Editor)
- Resource Type
- Book chapter
- Publication Details
- Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, pp.803-821
- Edition
- Second edition
- Publisher
- Humana Press; New York
- Series
- Cancer Drug Discovery and Development
- DOI
- 10.1007/978-1-4614-9135-4_40
- eISSN
- 2196-9914
- ISSN
- 2196-9906
- Number of pages
- 19
- Language
- English
- Date published
- 2014
- Academic Unit
- Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984695799902771
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