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Clinical Studies of the Modulation of Ftorafur
Book chapter   Peer reviewed

Clinical Studies of the Modulation of Ftorafur

Patrick J. Creaven, Youcef M. Rustum, Nicholas J. Petrelli and Vera A. Gorbunova
Novel Approaches to Selective Treatments of Human Solid Tumors, pp.253-263
Advances in Experimental Medicine and Biology, Springer US
1993
DOI: 10.1007/978-1-4615-2488-5_25
PMID: 8178722

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Abstract

Biochemical modulation of fluoropyrimidines has now been evaluated clinically for more than a decade in the treatment of colorectal carcinoma and more recently in other tumors. Although real progress has been made in terms of increased response rate1”3 there has been little, if any, effect on survival. Several approaches have been used in an attempt to improve on response rates and impact on survival with fluoropyrimidine modulation. Some of these are listed in Table 1.
Colorectal Carcinoma Folinic Acid Metastatic Colorectal Carcinoma Pyrimidine Nucleoside Roswell Park Cancer Institute

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